BJG-03-025

Chemical Structure : BJG-03-025

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货号: PC-72153Not For Human Use, Lab Use Only.

BJG-03-025 is a potent, highly selective FAK tyrosine kinase inhibitor with biochemical IC50 of 20.2 nM.

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生物&药学活性

BJG-03-025 is a potent, highly selective FAK tyrosine kinase inhibitor with biochemical IC50 of 20.2 nM.
BJG-03-025 demonstrates excellent kinome selectivity was profiled by KINOMEscan screening, PLK1 proved to be a false positive with IC50 of 8.3 uM, 100-300-fold selective for FAK.
BJG-03-025 displays antiproliferative activity in three-dimensional (3D)-breast and gastric cancer models and impacts cellular signaling and migration.
BJG-03-025 decreased phosphorylated FAK (pFAK Y397) in gastric cancer CDH1–/–RHOAY42C/+ organoid model, decreased aberrant signaling and proliferation of gastric cancer organoids.

物理化学性质&存储条件

分子量	563.725
分子式	C28H37N9O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-2,4,9-trimethyl-4,9-dihydro-10H-pyrimido[5,4-b]thiazolo[5,4-e][1,4]diazepin-10-one

参考文献

1. Brian J Groendyke, et al. ACS Med Chem Lett. 2020 Dec 14;12(1):30-38.

BJG-03-025

生物&药学活性

物理化学性质&存储条件

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BJG-03-025

生物&药学活性

物理化学性质&存储条件

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