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首页-小分子抑制剂&激动剂-GPCR-TGR5 (GPCR19, GPR131, GPBAR1)-BIX02694
BIX02694

Chemical Structure : BIX02694

CAS No.:

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BIX02694 (BIX 02694)

货号: PC-20447Not For Human Use, Lab Use Only.

BIX02694 (BIX 02694) is a highly potent, in vivo-active TGR5 (GPBAR1) agonist with EC50 of 9 nM in AlphaScreen cAMP assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BIX02694 (BIX 02694) is a highly potent, in vivo-active TGR5 (GPBAR1) agonist with EC50 of 9 nM in AlphaScreen cAMP assays.
    BIX02694 cross reacts with mouse GPBAR1 and can impact monocyte response to LPS.
    BIX02694 reduces monocyte activation in vitro and proinflammatory cytokine production in vivo reduces EAE disease severity.
     

    物理化学性质&存储条件

    分子量 491.03
    分子式 C28H31ClN4O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(9-(1-(4-chlorophenyl)-4-methyl-1H-imidazole-5-carbonyl)-9-azabicyclo[3.3.1]nonan-3-yl)-N,N-dimethylbenzamide

    参考文献

    1. Nuruddeen D Lewis, et al. PLoS One. 2014 Jun 26;9(6):e100883.

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