BIX02189 |CAS:1265916-41-3 Probechem Biochemicals

Chemical Structure : BIX02189

CAS No.: 1265916-41-3

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BIX02189 (BIX 02189;BIX-02189)

货号: PC-42870Not For Human Use, Lab Use Only.

BIX02189 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity (IC50=59 nM), does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

规格	价格	库存
10 mg	￥1950	In stock
50 mg	￥5850	In stock
100 mg	￥9850	In stock
500 mg		Get quote

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生物&药学活性

BIX02189 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity (IC50=59 nM), does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
BIX02189 blocks phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells, also inhibits transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade.
BIX02189 blocks ERK5 signaling and suppresses NGF-induced neurite outgrowth in PC12 cells.

物理化学性质&存储条件

分子量	440.5368
分子式	C27H28N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 49.4 mg/mL
Chemical Name/SMILES	1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-, (3Z)-

参考文献

1. Tatake RJ,et al. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.

2. Obara Y, et al. J Biol Chem. 2009 Aug 28;284(35):23564-73.

BIX02189 (BIX 02189;BIX-02189)

生物&药学活性

物理化学性质&存储条件

参考文献

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BIX02189 (BIX 02189;BIX-02189)

生物&药学活性

物理化学性质&存储条件

参考文献

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