BIT225 | HIV-1 Vpu inhibitor | Probechem Biochemicals

Chemical Structure : BIT225

CAS No.: 917909-71-8

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BIT225 (BIT-225 )

货号: PC-24825Not For Human Use, Lab Use Only.

BIT225 (BIT-225) is a specific small molecule inhibitor of HIV-1 Vpu ion channel activity, inhibits the release of HIV-1 in human MDM with EC50 of 2.25 uM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

BIT225 (BIT-225) is a specific small molecule inhibitor of HIV-1 Vpu ion channel activity, inhibits the release of HIV-1 in human MDM with EC50 of 2.25 uM.
BIT225 demonstrates strong activities against a wide panel of HIV-1 isolates, greatly inhibits both single-drug- and multidrug-resistant viral isolates (HIV-1 strain G-92NG003-G3, EC50=1.6 uM).
BIT225 has no effect upon the replication of HIV-2, which lacks Vpu protein.
BIT225 is post-virus integration, with no direct effects on the HIV-1 enzymes RT and protease.

物理化学性质&存储条件

分子量	293.33
分子式	C16H15N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide

参考文献

1. Khoury G, et al. Antimicrob Agents Chemother. 2010 Feb;54(2):835-45.

BIT225 (BIT-225 )

生物&药学活性

物理化学性质&存储条件

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BIT225 (BIT-225 )

生物&药学活性

物理化学性质&存储条件

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