BIO922 | Probechem Biochemicals

Chemical Structure : BIO922

CAS No.: 2733445-49-1

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BIO922 (BIO 922;BIO-922)

货号: PC-35656Not For Human Use, Lab Use Only.

BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors.

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10 mg	￥4880	In stock
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生物&药学活性

BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors.
BIO922 shows >100-fold selectivity over other related PDZ domain-containing proteins, namely PSD-95 and GRIP.
BIO922 stabilizes surface GluA2 and attenuates Aβ-mediated increase in intracellular calcium concentration in cultured hippocampal neurons.

物理化学性质&存储条件

分子量	545.987
分子式	C28H27ClF3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(1-(6-chloroquinolin-8-yl)-4-(4-(trifluoromethyl)phenyl)piperidine-4-carboxamido)-3-cyclopropylpropanoic acid

参考文献

1. Lin EYS, et al. Sci Rep. 2018 Sep 7;8(1):13438.

2. Alfonso S, et al. Eur J Neurosci. 2014 Apr;39(7):1225-33.

BIO922 (BIO 922;BIO-922)

生物&药学活性

物理化学性质&存储条件

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BIO922 (BIO 922;BIO-922)

生物&药学活性

物理化学性质&存储条件

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