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首页-小分子抑制剂&激动剂-Others-Other Targets-BIO 8898
BIO 8898

Chemical Structure : BIO 8898

CAS No.: 402564-79-8

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BIO 8898 (BIO8898)

货号: PC-62356Not For Human Use, Lab Use Only.

BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM.
    BIO 8898 inhibits CD40L-dependent apoptosis in a cellular assay.

    物理化学性质&存储条件

    分子量 909.145
    分子式 C53H64N8O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(2'-(([1,1'-biphenyl]-3-ylmethyl)carbamoyl)-6,6'-bis((S)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-[4,4'-bipyridine]-2-carboxamido)-2-cyclohexylacetic acid

    参考文献

    1. Silvian LF, et al. ACS Chem Biol. 2011 Jun 17;6(6):636-47.

    2. Ganesan L, et al. Pharmazie. 2012 May;67(5):374-9.

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