BIO5192 |CAS:327613-57-0 Probechem Biochemicals

Chemical Structure : BIO5192

CAS No.: 327613-57-0

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BIO5192 (BIO-5192, BIO 5192)

货号: PC-61300Not For Human Use, Lab Use Only.

BIO5192 (BIO-5192) is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

BIO5192 (BIO-5192) is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
BIO5192 displays selectively over a range of other integrins (IC50 are 138, 1053, > 500 and > 10,000 nM for α9β1, α2β1, α4β7 and αIIbβ3, respectively).
BIO5192 mobilizes hematopoietic stem and progenitor cells (HSPCs) alone or combined with plerixafor (AMD3100).

物理化学性质&存储条件

分子量	817.78
分子式	C38H46Cl2N6O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid

参考文献

1. Leone DR, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1150-62.

2. Theien BE, et al. Blood. 2003 Dec 15;102(13):4464-71.

3. Ramirez P, et al. Blood. 2009 Aug 13;114(7):1340-3.

4. Bao F, et al. Exp Neurol. 2008 Dec;214(2):160-7.

BIO5192 (BIO-5192, BIO 5192)

生物&药学活性

物理化学性质&存储条件

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BIO5192 (BIO-5192, BIO 5192)

生物&药学活性

物理化学性质&存储条件

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