BIO (6BIO, GSK3 Inhibitor IX, MLS 2052) | GSK-3 inhibitor

Chemical Structure : BIO

CAS No.: 667463-62-9

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BIO (6BIO;6-BIO;GSK 3 IX;GSK 3 Inhibitor IX;MLS 2052;MLS2052)

货号: PC-42664Not For Human Use, Lab Use Only.

BIO (6BIO, GSK-3 Inhibitor IX, MLS 2052) is a cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

BIO (6BIO, GSK-3 Inhibitor IX, MLS 2052) is a cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.
BIO also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM).
BIO maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog.
BIO promotes proliferation in mammalian cardiomyocytes.

物理化学性质&存储条件

分子量	356.1735
分子式	C16H10BrN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 23 mg/mL
Chemical Name/SMILES	2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-

参考文献

1. Meijer L, et al. Chem Biol. 2003 Dec;10(12):1255-66.

2. Tseng AS, et al. Chem Biol. 2006 Sep;13(9):957-63.

3. Sato N, et al. Nat Med. 2004 Jan;10(1):55-63.

BIO (6BIO;6-BIO;GSK 3 IX;GSK 3 Inhibitor IX;MLS 2052;MLS2052)

生物&药学活性

物理化学性质&存储条件

参考文献

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BIO (6BIO;6-BIO;GSK 3 IX;GSK 3 Inhibitor IX;MLS 2052;MLS2052)

生物&药学活性

物理化学性质&存储条件

参考文献

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