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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Autotaxin-BIO-32546
BIO-32546

Chemical Structure : BIO-32546

CAS No.: 1548743-66-3

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BIO-32546 (BIO 32546)

货号: PC-72060Not For Human Use, Lab Use Only.

BIO-32546 (BIO 32546) is a potent, selective, orally bioavailable, brain-penetrable Autotaxin inhibitor with IC50 of 1 nM.

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2 mg ￥2780 In stock
5 mg ￥4580 In stock
10 mg ￥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BIO-32546 (BIO 32546) is a potent, selective, orally bioavailable, brain-penetrable Autotaxin inhibitor with IC50 of 1 nM.
BIO-32546 inhibits plasna hLPA level with IC50 of 53 nM.

物理化学性质&存储条件

分子量 543.55
分子式 C28H31F6NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

10 mM in DMSO (5.4 mg/mL)
Chemical Name/SMILES

8-[(1S)-1-[8-(Trifluoromethyl)-7-[[cis-4-(trifluoromethyl)cyclohexyl]oxy]-2-naphthalenyl]ethyl]-8-azabicyclo[3.2.1]octane-3-carboxylic acid

参考文献

1. Bin Ma, et al. ACS Med Chem Lett. 2021 Jun 14;12(7):1124-1129.

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