BIM5078 | HNF4α antagonist | Probechem Biochemicals

Chemical Structure : BIM5078

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BIM5078 (BIM-5078)

货号: PC-72022Not For Human Use, Lab Use Only.

BIM5078 (BIM-5078) is a potent synthetic HNF4α antagonist, binds to HNF4α with high affinity (EC50=11.9 nM) and modulates HNF4α target genes and metabolic processes controlled by HNF4α.

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生物&药学活性

BIM 5078 (BIM-5078) is a potent synthetic HNF4α antagonist, binds to HNF4α with high affinity (EC50=11.9 nM) and modulates HNF4α target genes and metabolic processes controlled by HNF4α.
BIM 5078 potently repressed HNF4α expression in T6PNE and in the HepG2 hepatoma line, which has exceptionally high levels of HNF4α expression.
BIM 5078 also affected a subset of genes with no known HNF4α binding sites.
BIM5078 inhibited insulin gene expression, significantly decreased the association of E47 with the distal (E2) but not the proximal (E1) E-box of the insulin promoter, association of PDX-1 was significantly decreased.

物理化学性质&存储条件

分子量	351.761
分子式	C14H10ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((2-chloro-5-nitrophenyl)sulfonyl)-2-methyl-1H-benzo[d]imidazole

参考文献

1. Alice Kiselyuk, et al. Chem Biol. 2012 Jul 27;19(7):806-18.

BIM5078 (BIM-5078)

生物&药学活性

物理化学性质&存储条件

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BIM5078 (BIM-5078)

生物&药学活性

物理化学性质&存储条件

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