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首页-小分子抑制剂&激动剂-GPCR-Leukotriene Receptor-BIIL260
BIIL260

Chemical Structure : BIIL260

CAS No.: 204974-93-6

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BIIL260 (BIIL 260, BIIL-260)

货号: PC-63301Not For Human Use, Lab Use Only.

BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM.
    BIIL260 potently inhibits LTB(4)-induced intracellular Ca(2+) release in human neutrophils with IC50 of 0.82 nM, interacts with the LTB(4) receptor in a saturable, reversible, and competitive manner.

    物理化学性质&存储条件

    分子量 466.581
    分子式 C30H30N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[[3-[[4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy]methyl]phenyl]methoxy]benzenecarboximidamide

    参考文献

    1. Hori T, et al. Nat Chem Biol. 2018 Mar;14(3):262-269.

    2. Birke FW, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.

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