BIIB021 |CAS:848695-25-0 Probechem Biochemicals

Chemical Structure : BIIB021

CAS No.: 848695-25-0

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BIIB021 (CNF2024;BIIB-021;BIIB 021;CNF 2024;CNF-2024)

货号: PC-42459Not For Human Use, Lab Use Only.

BIIB021 is a potent, selective, orally available HSP90 inhibitor with Ki of 1.7 nM for Hsp90α.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

BIIB021 is a potent, selective, orally available HSP90 inhibitor with Ki of 1.7 nM for Hsp90α.
BIIB021 displays no significant activity against a broad panel of protein kinases, and Na+K+ ATPase.
BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and upregulates expression of Hsp70 and Hsp27 in tumor cells.
BIIB021 inhibits cell growth and induces cell death in cell lines from a variety of tumor types at nanomolar concentrations (IC50=60 nM in N87 cells).
BIIB021 exhibits antitumor effects in vivo.

物理化学性质&存储条件

分子量	318.7615
分子式	C14H15ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 45 mg/mL
Chemical Name/SMILES	9H-Purin-2-amine, 6-chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-

参考文献

1. Kasibhatla SR, et al. J Med Chem. 2007 Jun 14;50(12):2767-78.

2. Lundgren K, et al. Mol Cancer Ther. 2009 Apr;8(4):921-9.

3. Böll B, et al. Clin Cancer Res. 2009 Aug 15;15(16):5108-16.

4. Gopalakrishnan R, et al. Clin Cancer Res. 2013 Sep 15;19(18):5016-26.

BIIB021 (CNF2024;BIIB-021;BIIB 021;CNF 2024;CNF-2024)

生物&药学活性

物理化学性质&存储条件

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BIIB021 (CNF2024;BIIB-021;BIIB 021;CNF 2024;CNF-2024)

生物&药学活性

物理化学性质&存储条件

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