欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-BIIB-TTBKi
BIIB-TTBKi

Chemical Structure : BIIB-TTBKi

CAS No.: 2735014-96-5

加入收藏

BIIB-TTBKi

货号: PC-22793Not For Human Use, Lab Use Only.

BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.
BIIB-TTBK1i demonstrates in vivo target engagement and kinome selectivity.
BIIB-TTBK1i (50 or 75mg/kg) reduces tau phosphorylation at disease relevant sites in vivo.

物理化学性质&存储条件

分子量 307.36
分子式 C17H17N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(1-(2-aminopyrimidin-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)-3-methylpent-1-yn-3-ol

参考文献

1. Dillon GM, et al. PLoS One. 2020 Apr 7;15(4):e0228771.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: