BIIB-TTBKi

Chemical Structure : BIIB-TTBKi

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货号: PC-22793Not For Human Use, Lab Use Only.

BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.

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生物&药学活性

BIIB-TTBK1i is a potent selective inhibitor of CNS-specific tau kinase Tau Tubulin Kinase 1 (TTBK1) with IC50 of 9.5 nM in recombinant kinase assay, inhibits tau phosphorylation at S422 (pS422) with IC50 of 9.75 nM in cell-based assays.
BIIB-TTBK1i demonstrates in vivo target engagement and kinome selectivity.
BIIB-TTBK1i (50 or 75mg/kg) reduces tau phosphorylation at disease relevant sites in vivo.

物理化学性质&存储条件

分子量	307.36
分子式	C17H17N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-(2-aminopyrimidin-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)-3-methylpent-1-yn-3-ol

参考文献

1. Dillon GM, et al. PLoS One. 2020 Apr 7;15(4):e0228771.

BIIB-TTBKi

生物&药学活性

物理化学性质&存储条件

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BIIB-TTBKi

生物&药学活性

物理化学性质&存储条件

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