BIBX 1382 |CAS:196612-93-8 Probechem Biochemicals

Chemical Structure : BIBX 1382

CAS No.: 196612-93-8

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BIBX 1382 (Falnidamol;BIBX-1382;BIBX1382)

货号: PC-42522Not For Human Use, Lab Use Only.

BIBX 1382 (Falnidamol) is a selective EGFR inhibitor with IC50 of 3 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

BIBX 1382 (Falnidamol) is a selective EGFR inhibitor with IC50 of 3 nM.
BIBX 1382 shows weak activity against HER2 (IC50=3.4 uM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
BIBX 1382 inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells; orally active in xenografts mice.

物理化学性质&存储条件

分子量	387.8418
分子式	C18H19ClFN7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 41 mg/mL
Chemical Name/SMILES	Pyrimido[5,4-d]pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-

参考文献

1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.

2. Hutzler JM, et al. Drug Metab Dispos. 2014 Oct;42(10):1751-60.

BIBX 1382 (Falnidamol;BIBX-1382;BIBX1382)

生物&药学活性

物理化学性质&存储条件

参考文献

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BIBX 1382 (Falnidamol;BIBX-1382;BIBX1382)

生物&药学活性

物理化学性质&存储条件

参考文献

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