BIBU1361 dihydrochloride | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : BIBU1361 dihydrochloride

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BIBU1361 dihydrochloride (BIBU 1361)

货号: PC-62999Not For Human Use, Lab Use Only.

BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).

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生物&药学活性

BIBU1361 dihydrochloride is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
BIBU1361 inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells (EC50=122 nM).
BIBU1361 demonstrates effectivity in tumour xenografts mice.

物理化学性质&存储条件

分子量	516.871
分子式	C22H29Cl3FN7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride

参考文献

1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.

2. Ghildiyal R, et al. Mol Carcinog. 2013 Dec;52(12):970-82.

BIBU1361 dihydrochloride (BIBU 1361)

生物&药学活性

物理化学性质&存储条件

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BIBU1361 dihydrochloride (BIBU 1361)

生物&药学活性

物理化学性质&存储条件

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