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首页-小分子抑制剂&激动剂-GPCR-Angiotensin Receptor-BIBS-39
BIBS-39

Chemical Structure : BIBS-39

CAS No.: 133085-33-3

BIBS-39 (BIBS39, BIBS 39)

货号: PC-45692Not For Human Use, Lab Use Only.

BIBS-39 (BIBS 39) is a selective nonpeptide angiotensin II receptor antagonist with Ki of 29 nM and 480 nM for AT1 and AT2 respectively.

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5 mg ¥1280 In stock
10 mg ¥1980 In stock
25 mg ¥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BIBS-39 (BIBS 39) is a selective nonpeptide angiotensin II receptor antagonist with Ki of 29 nM and 480 nM for AT1 and AT2 respectively.
BIBS-39 shows no high affinity for other receptors, shifts the AII concentration-contractile response curves in isolated rabbit aorta with pA2 of 8.14 and a slope of 1.06.
BIBS-39 shows effective antihypertensives in the model of the renal hypertensive rat.

物理化学性质&存储条件

分子量 524.6533
分子式 C32H36N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-6-[[(cyclohexylamino)carbonyl]amino]-1H-benzimidazol-1-yl]methyl]-

参考文献

1. Zhang J, et al. Eur J Pharmacol. 1992 Jul 21;218(1):35-41.

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