BIBO3304 | NPY1R antagonist | Probechem Biochemicals

Chemical Structure : BIBO3304

CAS No.: 191868-14-1

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BIBO3304 (BIBO 3304, BIBO-3304)

货号: PC-62525Not For Human Use, Lab Use Only.

BIBO3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.

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10 mg	￥2880	In stock
25 mg	￥4980	In stock
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生物&药学活性

BIBO3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.
BIBO3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor, human and rat Y5 receptor (IC50>1,000 nM).
BIBO3304 inhibits the feeding response induced by 1 mg NPY in mice, also completely abolishes PYY-induced inhibition of insulin release in vivo.

物理化学性质&存储条件

分子量	643.668
分子式	C31H36F3N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate

参考文献

1. Wieland HA, et al. Br J Pharmacol. 1998 Oct;125(3):549-55.

2. Capurro D, et al. Eur J Pharmacol. 1999 Jul 9;376(3):251-5.

3. Loh K, et al. Nat Commun. 2017 Sep 8;8(1):490.

4. Kask A, et al. Neuropharmacology. 2000 Apr 27;39(7):1292-302.

BIBO3304 (BIBO 3304, BIBO-3304)

生物&药学活性

物理化学性质&存储条件

参考文献

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BIBO3304 (BIBO 3304, BIBO-3304)

生物&药学活性

物理化学性质&存储条件

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