BI8622 |CAS:1875036-74-0 Probechem Biochemicals

Chemical Structure : BI8622

CAS No.: 1875036-74-0

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BI8622 (BI-8622;BI 8622)

货号: PC-63514Not For Human Use, Lab Use Only.

BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b).

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5 mg	￥2980	In stock
10 mg	￥4880	In stock
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50 mg		Get quote
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生物&药学活性

BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b).
BI8622 abolishes ubiquitination of MCL1 induced by ectopically expressed HUWE1 in HeLa cells with IC50 of 6.8 uM, suppresses colony formation of Ls174T cells with IC50 of 8.4 uM.
BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells, but not in stem and normal colon epithelial cells.
BI8622 stabilizes MYC-associated protein MIZ1.

物理化学性质&存储条件

分子量	426.524
分子式	C25H26N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(aminomethyl)phenyl)-6-(4-cyano-4-phenylpiperidin-1-yl)-5-methylpyrimidine-4-carboxamide

参考文献

1. Peter S, et al. EMBO Mol Med. 2014 Dec;6(12):1525-41.

BI8622 (BI-8622;BI 8622)

生物&药学活性

物理化学性质&存储条件

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BI8622 (BI-8622;BI 8622)

生物&药学活性

物理化学性质&存储条件

参考文献

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