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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-BI 689648
BI 689648

Chemical Structure : BI 689648

CAS No.: 1633009-87-6

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BI 689648 (BI-689648, BI689648)

货号: PC-60700Not For Human Use, Lab Use Only.

BI 689648 is a potent, selective, orally active aldosterone synthase (CYP11B2) inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase ((CYP11B1).

规格 价格 库存 数量
5 mg ￥2380 In stock
10 mg ￥3780 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BI 689648 is a potent, selective, orally active aldosterone synthase (CYP11B2) inhibitor with IC50 of 2 nM, displays 150-fold selectivity over related cortisol synthase ((CYP11B1).
BI 689648 demonstrates good in vivo profiling used an adrenocorticotropin-challenge model in which BI 689648 is >20-fold more selective compared with FAD286 and LCI699.

物理化学性质&存储条件

分子量 298.346
分子式 C16H18N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(5-methoxymethyl-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide

参考文献

1. Weldon SM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50.

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