BI 671800 | CRTH2 inhibitor | Probechem Biochemicals

Chemical Structure : BI 671800

CAS No.: 1093108-50-9

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BI 671800 (BI-671800)

货号: PC-61563Not For Human Use, Lab Use Only.

BI 671800 is a potent, oral prostaglandin D2 receptor (DP2/CRTH2) antagonist with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

BI 671800 is a potent, oral prostaglandin D2 receptor (DP2/CRTH2) antagonist with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively.
BI 671800 effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals

物理化学性质&存储条件

分子量	501.5
分子式	C25H26F3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6-bis(dimethylamino)-2-((4-((4-(trifluoromethyl)benzoyl)amino)phenyl)methyl)-5-pyrimidineacetic acid

参考文献

1. Krug N, et al. J Allergy Clin Immunol. 2014 Feb;133(2):414-9.

2. Hall IP, et al. Pulm Pharmacol Ther. 2015 Jun;32:37-44.

3. Miller D, et al. Allergy Asthma Proc. 2017 Mar 1;38(2):157-164.

4. Kupczyk M, et al. Drugs. 2017 Aug;77(12):1281-1294.

BI 671800 (BI-671800)

生物&药学活性

物理化学性质&存储条件

参考文献

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BI 671800 (BI-671800)

生物&药学活性

物理化学性质&存储条件

参考文献

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