BI 665915 |CAS:1360550-04-4 Probechem Biochemicals

Chemical Structure : BI 665915

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BI 665915 (BI665915;BI-665915)

货号: PC-35038Not For Human Use, Lab Use Only.

BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM.

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1 g		Get quote

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生物&药学活性

BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM.
BI 665915 displays no activity against other enzymes and receptors in the leukotriene pathway such as 5-LO, COX-1 and -2, phospholipase A2, LTA4 hydrolase, BLT1, and BLT2 (IC50s>10 uM).
BI 665915 shows functional inhibition of LTB4 production in human whole blood (IC50=45 nM).
BI 665915 demonstrates a dose-dependent DMPK relationship and inhibition of LTB4 production in vivo.

物理化学性质&存储条件

分子量	458.526
分子式	C24H26N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

参考文献

1. Takahashi H, et al. J Med Chem. 2015 Feb 26;58(4):1669-90.

BI 665915 (BI665915;BI-665915)

生物&药学活性

物理化学性质&存储条件

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BI 665915 (BI665915;BI-665915)

生物&药学活性

物理化学性质&存储条件

参考文献

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