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首页-小分子抑制剂&激动剂-GPCR-Melanin-concentrating Hormone Receptor (MCHR)-BI 186908
BI 186908

Chemical Structure : BI 186908

CAS No.: 1453500-36-1

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BI 186908 (BI186908)

货号: PC-61512Not For Human Use, Lab Use Only.

BI 186908 is a potent and selective MCH1 receptor (MCHR1) antagonist with IC50 of 22 nM, Ki of 14 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BI 186908 is a potent and selective MCH1 receptor (MCHR1) antagonist with IC50 of 22 nM, Ki of 14 nM.
    BI 186908 significantly reduces body weight comparable to sibutramine in a 4 week diet-induced obesity model in rats, possesses favorable DMPK and CMC properties.

    物理化学性质&存储条件

    分子量 422.485
    分子式 C23H26N4O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-5-((5-methoxypyridin-2-yl)methoxy)pyridazin-3(2H)-one

    参考文献

    1. Oost T, et al. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80.

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