BI 1810284 (ACBI2, BI 01810284) | SMARCA2 PROTAC | Probechem Biochemicals

Chemical Structure : BI 1810284

CAS No.: 2913161-19-8

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BI 1810284 (ACBI2, BI-1810284, BI 01810284)

货号: PC-20464Not For Human Use, Lab Use Only.

BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.

规格	价格	库存
2 mg	￥2580	In stock
5 mg	￥4280	In stock
10 mg	￥7280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

BI 1810284 (ACBI2, BI 01810284) is a potent, selective and orally bioavailable VHL-recruiting PROTAC degrader of SMARCA2 (DC50=1 nM in RKO cells), 30-fold selectivity over SMARCA4.
BI 1810284 (80 mg/kg, oral) induces lung cancer tumour growth inhibition in A549 tumour bearing mice.

物理化学性质&存储条件

分子量	1063.19
分子式	C57H69BrFN7O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyrrolidinecarboxamide, N-[(1S,4S)-6-[4-(4-bromo-7-cyclopentyl-5,7-dihydro-5-oxobenzimidazo[1,2-a]quinazolin-9-yl)-1-piperidinyl]-4-methyl-1-[4-(4-methyl-5-thiazolyl)phenyl]hexyl]-1-[(2S)-2-[2-(1-fluorocyclopropyl)-2-oxoethyl]-3,3-dimethyl-1-oxobutyl]-4-hydroxy-, (2S,4R)-

参考文献

1. Christiane Kofink, et al. Nat Commun. 2022 Oct 10;13(1):5969.

BI 1810284 (ACBI2, BI-1810284, BI 01810284)

生物&药学活性

物理化学性质&存储条件

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BI 1810284 (ACBI2, BI-1810284, BI 01810284)

生物&药学活性

物理化学性质&存储条件

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