BI 1265162 | ENaC inhibitor | Probechem Biochemicals

Chemical Structure : BI 1265162

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BI 1265162 (BI1265162, BI-1265162)

货号: PC-72898Not For Human Use, Lab Use Only.

BI 1265162 is a potent ENaC inhibitor, inhibits Na+ transport with IC50 3 nM and 8 nM in M1 and NCI-H441 cells, respectively.

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生物&药学活性

BI 1265162 is a potent ENaC inhibitor, inhibits Na+ transport with IC50 3 nM and 8 nM in M1 and NCI-H441 cells, respectively.
BI 1265162 dose-dependently inhibited Na+ transport and decreased water resorption in cell line models.
BI 1265162 reduced liquid absorption in rat lungs and increased MCC in sheep, with no effects on renal function in the animal models.
BI 1265162 alone and in combination with CF transmembrane conductance regulator (CFTR) modulators decreased water transport and increased MCC in both normal and CF airway human epithelial models.

物理化学性质&存储条件

分子量	680.01
分子式	C24H34ClN7O5P.C2F3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-amino-6-chloropyrazine-2-carboxamido)methyl)-6-(2-((2-((dimethylphosphoryl)methoxy)ethyl)amino)-2-oxoethoxy)-1,3-diethyl-1H-benzo[d]imidazol-3-ium

参考文献

1. Peter Nickolaus, et al. ERJ Open Res. 2020 Dec 7;6(4):00429-2020.

2. Mall MA. Eur Respir J. 2020 Dec 24;56(6):2000946.

BI 1265162 (BI1265162, BI-1265162)

生物&药学活性

物理化学性质&存储条件

参考文献

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BI 1265162 (BI1265162, BI-1265162)

生物&药学活性

物理化学性质&存储条件

参考文献

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