BI-D1870 |CAS:501437-28-1 Probechem Biochemicals

Chemical Structure : BI-D1870

CAS No.: 501437-28-1

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BI-D1870 (BI-D 1870)

货号: PC-42627Not For Human Use, Lab Use Only.

BI-D1870 is a potent, specific ATP-competitive inhibitor of RSK isoforms with IC50 of 10-30 nM for RSK1/2/3/4.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

BI-D1870 is a potent, specific ATP-competitive inhibitor of RSK isoforms with IC50 of 10-30 nM for RSK1/2/3/4.
BI-D1870 shows weak inhibition on PLK1 (IC50=100 nM) and no activity against MSK1.
BI-D1870 prevents the RSK-mediated phorbol ester- and EGF-induced phosphoryl-ation of GSK-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells.

物理化学性质&存储条件

分子量	391.415
分子式	C19H23F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6(5H)-Pteridinone, 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-

参考文献

1. Sapkota GP, et al. Biochem J. 2007 Jan 1;401(1):29-38.

2. Neise D, et al. Cell Death Dis. 2013 Oct 17;4:e859.

3. Fonseca BD, et al. J Biol Chem. 2011 Aug 5;286(31):27111-22.

BI-D1870 (BI-D 1870)

生物&药学活性

物理化学性质&存储条件

参考文献

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BI-D1870 (BI-D 1870)

生物&药学活性

物理化学性质&存储条件

参考文献

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