BI-99179 |CAS:1291779-76-4 Probechem Biochemicals

Chemical Structure : BI-99179

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BI-99179 (BI99179)

货号: PC-35031Not For Human Use, Lab Use Only.

BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM.

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生物&药学活性

BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS, FASN) with IC50 of 79 nM.
BI-99179 demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM.
BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target.

物理化学性质&存储条件

分子量	391.471
分子式	C23H25N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3S)-N-(4-(benzo[d]oxazol-2-yl)phenyl)-N-methyl-3-propionamidocyclopentane-1-carboxamide

参考文献

1. Kley JT, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.

BI-99179 (BI99179)

生物&药学活性

物理化学性质&存储条件

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BI-99179 (BI99179)

生物&药学活性

物理化学性质&存储条件

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