BI-9774 | AMPK activator | Probechem Biochemicals

Chemical Structure : BI-9774

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BI-9774 (BI 9774)

货号: PC-20056Not For Human Use, Lab Use Only.

BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay.
BI-9774 activates all human AMPK isoforms tested as well as rat AMPK (α1β1γ1) with EC50 values below 100 nM.
BI-9774 could acutely improve glucose tolerance, increase muscle glucose uptake and lactate and glycogen in rodents.
BI-9774 also showed reduction in inotropism and heart rate in acute cardiovascular studies in anesthetized rats.

物理化学性质&存储条件

分子量	541.02
分子式	C26H25ClN4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((4'-(6-chloro-2-(((3R,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl)oxy)-3H-imidazo[4,5-b]pyridin-5-yl)-[1,1'-biphenyl]-4-yl)imino)dimethyl-l6-sulfanone

参考文献

1. Patent WO2015007669 A1.

BI-9774 (BI 9774)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BI-9774 (BI 9774)

生物&药学活性

物理化学性质&存储条件

参考文献

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