欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-GPR88-BI-9508
BI-9508

Chemical Structure : BI-9508

CAS No.:

加入收藏

BI-9508 (BI 9508)

货号: PC-22616Not For Human Use, Lab Use Only.

BI-9508 is a potent, selective and brain penetrant GPR88 agonist with EC50 of 47 nM in hGPR88 Gi1 BRET assay, Emax of 110%.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BI-9508 is a potent, selective and brain penetrant GPR88 agonist with EC50 of 47 nM in hGPR88 Gi1 BRET assay, Emax of 110%.
BI-9508 has EC50 of 94 nM for mGPR88.
BI-9508 shows acceptable selectivity in the CEREP SafetyScreen44
BI-9508 show improved pharmacokinetic properties and dosing for future in vivo studies in rodents.

物理化学性质&存储条件

分子量 521.57
分子式 C28H29F2N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,2R)-N-(2-(Difluoromethoxy)ethyl)-N-(4-(4-isopropoxyphenyl)-1-methyl-1H-indazol-7-yl)-2-(pyrimidin-4-yl)cyclopropane-1-carboxamide

参考文献

1. Fer M, et al. J Med Chem. 2024 Jul 1. doi: 10.1021/acs.jmedchem.4c00665.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: