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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-BI-9321 trihydrochloride
BI-9321 trihydrochloride

Chemical Structure : BI-9321 trihydrochloride

CAS No.: 387510-87-2

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BI-9321 trihydrochloride (BI 9321 trihydrochloride)

货号: PC-72294Not For Human Use, Lab Use Only.

BI-9321 trihydrochloride (BI 9321) is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BI-9321 trihydrochloride (BI 9321) is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM.
BI-9321 displays no significant inhibition against a selection of 31 diverse kinases, closest family members NSD2-PWWP1, BRD4 and KDM1B.
BI-9321 targets the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 uM.
BI-9321 downregulated Myc messenger RNA expression and reduces proliferation in MOLM-13 cells, BI-9321 inhibited proliferation of both MOLM-13 (IC50=26.8 uM) and RN2 cells (IC50=13 uM).
BI-9321 enhanced the JQ1-dependent proliferation phenotype in the MOLM-13 cell line.

物理化学性质&存储条件

分子量 469.81
分子式 C22H24Cl3FN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in DMSO (46.9 mg/mL)
Chemical Name/SMILES

(4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride

参考文献

1. Böttcher J, et al. Nat Chem Biol. 2019 Aug;15(8):822-829.

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