BI-8128 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : BI-8128

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BI-8128 (BI 8128)

货号: PC-21465Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

BI-8128 is a potent, selective, reversible and orally bioavailable fourth generation EGFR inhibitor, potently inhibits oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C797S.
BI-8128 demonstrates potent, low nanomolar anti-proliferative activity in Ba/F3 cells that are dependent on the activity of human EGFR variants del19, del19 T790M C797S, L858R, and L858R T790M C797S.
BI-8128 potently inhibits the two major primary oncogenic EGFR variants del19 and L858R, in the presence and absence of the acquired EGFR resistance mutations T790M and C797S, while sparing wild-type EGFR.

物理化学性质&存储条件

分子量	610.72
分子式	C32H38N10O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,4R)-5-(2-(4-(2-methoxyethyl)piperazin-1-yl)-6-(6-(4-methoxypyridin-3-yl)-4-methyl-1H-pyrazolo[4,3-c]pyridin-1-yl)-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)-2-oxa-5-azabicyclo[2.2.1]heptane

BI-8128 (BI 8128)

生物&药学活性

物理化学性质&存储条件

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BI-8128 (BI 8128)

生物&药学活性

物理化学性质&存储条件

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