BI-78D3 |CAS:883065-90-5 Probechem Biochemicals

Chemical Structure : BI-78D3

CAS No.: 883065-90-5

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BI-78D3 (BI 78D3;BI78D3)

货号: PC-42552Not For Human Use, Lab Use Only.

BI-78D3 is a small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

BI-78D3 is a small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM.
BI-78D3 targets the JNK-JIP interaction site and dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell.
BI-78D3 blocks JNK dependent Con A-induced liver damage, restores insulin sensitivity in mouse models of type 2 diabetes.

物理化学性质&存储条件

分子量	379.37106
分子式	C13H9N5O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	3H-1,2,4-Triazol-3-one, 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-

参考文献

1. Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13.

2. Strittmatter F, et al. Br J Pharmacol. 2012 Jul;166(6):1926-35.

3. Posthumadeboer J, et al. Oncotarget. 2012 Oct;3(10):1169-81.

BI-78D3 (BI 78D3;BI78D3)

生物&药学活性

物理化学性质&存储条件

参考文献

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BI-78D3 (BI 78D3;BI78D3)

生物&药学活性

物理化学性质&存储条件

参考文献

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