BI-7190 | BPTF inhibitor | Probechem Biochemicals

Chemical Structure : BI-7190

加入收藏

BI-7190 (BI 7190)

货号: PC-20122Not For Human Use, Lab Use Only.

BI-7190 (BI 7190) is a potent, selective chemical probe targeting the bromodomain of BPTF with binding Kd of 3.5 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BI-7190 (BI 7190) is a potent, selective chemical probe targeting the bromodomain of BPTF with binding Kd of 3.5 nM.
BI-7190 shows high binding affinity for bromodomain BPTF with Kd of 131 nM in ITC assays.
BI-7190 shows decreased the affinity for BRD9 (Kd=18.4 nM).
BI-7190 showed only weak cellular target engagement against the off-target bromodomains.
BI-7190 (1 uM) induced minor transcriptional modulation in NCI-H1437 cells over 120 h, including CLCF1, CLMP, and CLSPN.
BI-7190 is a suitable tool compound for in vivo efficacy and mode-of-action studies, as well as for PROTAC design.

物理化学性质&存储条件

分子量	381.52
分子式	C23H31N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-methoxy-4-(1-(4-methylpiperazin-1-yl)cyclopropyl)phenyl)-1,3,4-trimethylpyridin-2(1H)-one

参考文献

1. Martinelli P, et al. ChemMedChem. 2023 Jan 17:e202200686.

BI-7190 (BI 7190)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BI-7190 (BI 7190)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.