BI-6c9

Chemical Structure : BI-6c9

CAS No.: 791835-21-7

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货号: PC-49740Not For Human Use, Lab Use Only.

BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.

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5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.
BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
BI-6C9 prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation.
BH3 interacting domain death agonist (Bid), a substrate of caspase-8, is activated in the Fas/Apo-1 (CD95), tumor necrosis factor (TNF)-α, and tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptor-mediated cell death.

物理化学性质&存储条件

分子量	471.59
分子式	C23H25N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide

参考文献

1. Zhou H, et al. Mol Cancer. 2014 Mar 16;13:59.

2. Landshamer, S., et al. Cell Death Differ. 15(10), 1553-1563 (2008).

3. Culmsee, C. et al. J. Neurosci. 25(44), 10262-10272 (2005).

4. Becattini, B.,et al. Proc. Natl. Acad. Sci. USA 103(3), 12602-12606 (2006).

BI-6c9

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BI-6c9

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