BI-69A11 |CAS:1233322-09-2 Probechem Biochemicals

Chemical Structure : BI-69A11

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BI-69A11 (BI 69A11)

货号: PC-70086Not For Human Use, Lab Use Only.

BI-69A11 is a potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.

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1 g		Get quote

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生物&药学活性

BI-69A11 is a potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1.
BI-69A11 displays no activity for other protein kinases including Abl1, p38α, JNK, and PI3K (IC50>100 uM).
BI-69A11 causes partial inhibition of AKT phosphorylation on S473 on melanoma cells at 3 uM.
BI-69A11 reduces AKT protein expression and AKT association with HSP-90.|
BI-69A11 caused effective regression of melanoma tumor xenografts.

物理化学性质&存储条件

分子量	425.872
分子式	C25H16ClN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one(E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one

参考文献

1. Gaitonde S, et al. Pigment Cell Melanoma Res. 2009 Apr;22(2):187-95.

2. Feng Y, et al. Pigment Cell Melanoma Res. 2013 Jan;26(1):136-42.

3. Pal I, et al. Br J Cancer. 2014 Jul 8;111(1):101-11.

BI-69A11 (BI 69A11)

生物&药学活性

物理化学性质&存储条件

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BI-69A11 (BI 69A11)

生物&药学活性

物理化学性质&存储条件

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