BI-4142 | HER2 inhibitor | Probechem Biochemicals

Chemical Structure : BI-4142

CAS No.: 2682003-36-5

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BI-4142 (BI 4142)

货号: PC-49226Not For Human Use, Lab Use Only.

BI-4142 (BI 4142) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 5 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BI-4142 (BI 4142) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 5 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR.
BI-4142 (5 uM) inhibits the proliferation of HER2-dependent cell lines with IC50 values of 10 nM, 18 nM, 270 nM and 2400 nM against HEK HER2YVMA, Ba/F3 HER2YVMA, HEK EGFRWT and Ba/F3 EGFRWT, respectively.
BI-4142 dose-dependently decreases pHER2 and pERK levels in NCI-H2170 HER2YVMA and PC-9 HER2YVMA cells.
BI-4142 inhibits tumor growth and inhibits oncogenic signaling in preclinical xenograft models of HER2 exon 20 mutant non-small cell lung cancer.

物理化学性质&存储条件

分子量	521.57
分子式	C28H27N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propen-1-one, 1-[4-[8-[[3-methyl-4-[(1-methyl-1H-benzimidazol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-1-piperazinyl]-

参考文献

1. To C, et al. Nat Cancer. 2022 Apr;3(4):402-417.

BI-4142 (BI 4142)

生物&药学活性

物理化学性质&存储条件

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BI-4142 (BI 4142)

生物&药学活性

物理化学性质&存储条件

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