BI-3231 | HSD17B13 inhibitor | Probechem Biochemicals

Chemical Structure : BI-3231

CAS No.: 2894848-07-6

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BI-3231 (BI 3231)

货号: PC-49633Not For Human Use, Lab Use Only.

BI-3231 (BI 3231) is a potent, selective HSD17B13 (hydroxysteroid 17β-dehydrogenase 13) inhibitor with enzyme IC50 of 1 and 14 nM for human and mouse HSD17B13, respectively.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

BI-3231 (BI 3231) is a potent, selective HSD17B13 (hydroxysteroid 17β-dehydrogenase 13) inhibitor with enzyme IC50 of 1 and 14 nM for human and mouse HSD17B13, respectively.
BI-3231 displays excellent selectivity versus the structurally related homolog HSD17B11 (IC50>10 uM), as well as good selectivity in a commercial SafetyScreen44 panel, Cerep.
BI-3231 is the first potent and selective chemical probe reported for HSD17B13, a potential new target for the treatment of NASH and other liver diseases.

物理化学性质&存储条件

分子量	380.37
分子式	C16H14F2N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((5-(2,4-difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl)methyl)-3-ethyl-5-methylpyrimidine-2,4(1H,3H)-dione

参考文献

1. Thamm S, et al. J Med Chem. 2023 Feb 2. doi: 10.1021/acs.jmedchem.2c01884.

BI-3231 (BI 3231)

生物&药学活性

物理化学性质&存储条件

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BI-3231 (BI 3231)

生物&药学活性

物理化学性质&存储条件

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