BI-1950 | LFA-1 inhibitor | Probechem Biochemicals

Chemical Structure : BI-1950

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BI-1950 (BI1950)

货号: PC-35035Not For Human Use, Lab Use Only.

BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM.

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生物&药学活性

BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM.
BI-1950 displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function.
BI-1950 inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively.
BI-1950 exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo.

物理化学性质&存储条件

分子量	646.504
分子式	C32H26Cl2FN7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(4-cyanobenzyl)-1-(3,5-dichloro-4-fluorophenyl)-3-methyl-2-oxo-N-((S)-1-oxo-1-((1-(pyridin-2-yl)cyclopropyl)amino)propan-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazole-5-carboxamide

BI-1950 (BI1950)

生物&药学活性

物理化学性质&存储条件

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BI-1950 (BI1950)

生物&药学活性

物理化学性质&存储条件

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