BI-1388 | HCV NS3 protease inhibitor | Probechem Biochemicals

Chemical Structure : BI-1388

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BI-1388 (BI1388, BI 1388)

货号: PC-35032Not For Human Use, Lab Use Only.

BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K.

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生物&药学活性

BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K.
BI-1388 was shown to be highly selective against other serine/cysteine proteases, binds to the active site of NS3 that is located in the shallow and broad protein-protein interaction surface of the protease- and the helicase domain of the enzyme.

物理化学性质&存储条件

分子量	819.975
分子式	C41H53N7O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,6S,13aR,14aR,16aS,Z)-2-((2-Isopropoxy-7-methoxy-8-methylquinolin-4-yl)oxy)-6-(1-methyl-1H-pyrazole-3-carboxamido)-N-((1-methylcyclopropyl)sulfonyl)-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacycl

参考文献

1. Tsantrizos YS, et al. Angew Chem Int Ed Engl. 2003 Mar 28;42(12):1356-60.

BI-1388 (BI1388, BI 1388)

生物&药学活性

物理化学性质&存储条件

参考文献

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BI-1388 (BI1388, BI 1388)

生物&药学活性

物理化学性质&存储条件

参考文献

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