BI-1124 | Cathepsin S inhibitor | Probechem Biochemicals

Chemical Structure : BI-1124

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BI-1124 (BI 1124)

货号: PC-38291Not For Human Use, Lab Use Only.

BI-1124 (BI 1124) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 7 nM, >40-fold selectivity over Cathepsin L/K/B.

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生物&药学活性

BI-1124 (BI 1124) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 7 nM, >40-fold selectivity over Cathepsin L/K/B.
BI-1124 had a superior PK profile and showed dose-dependent inhibition of the ovalbumin induced IL-2 secretion in a T cell receptor transgenic DO11 mouse model with an IC50 of 0.3 mg/kg.

物理化学性质&存储条件

分子量	421.586
分子式	C22H39N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-((4-cyano-1-propylpiperidin-4-yl)amino)-5,5-dimethyl-1-oxohexan-2-yl)morpholine-4-carboxamide

BI-1124 (BI 1124)

生物&药学活性

物理化学性质&存储条件

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BI-1124 (BI 1124)

生物&药学活性

物理化学性质&存储条件

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