BHPI

Chemical Structure : BHPI

CAS No.: 56632-39-4

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货号: PC-43234Not For Human Use, Lab Use Only.

BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells.
BHPI distorts this normal action of E2–ERα and induces a massive and sustained ERα-dependent activation of the unfolded protein response (UPR), persistent inhibition of protein synthesis, converting UPR activation from cytoprotective to cytotoxic.
BHPI completely blocked proliferation of ERα+ cancer cells at 100-1000 nM, induces tumor regression in mouse xenograft of MCF-7 cells.

物理化学性质&存储条件

分子量	331.3646
分子式	C21H17NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥150 mg/mL
Chemical Name/SMILES	2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-

参考文献

1. Andruska ND, et al. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42.

2. Zheng X, et al. Oncotarget. 2016 Jul 24;9(19):14741-14753.

3. Mao C, et al. Sci Rep. 2016 Oct 7;6:34753.

BHPI

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物理化学性质&存储条件

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