BGC20-1531 |CAS:1962928-26-2 Probechem Biochemicals

Chemical Structure : BGC20-1531

CAS No.: 1962928-26-2

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BGC20-1531 (PGN-1531;AP 1531;BGC 20-1531)

货号: PC-36058Not For Human Use, Lab Use Only.

BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8).

规格	价格	库存
10 mg	￥1880	In stock
50 mg	￥4580	In stock
100 mg	￥7880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP4 antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8).
BGC20-1531 shows no appreciable affinity at a wide range of other receptors (including other prostanoid receptors), channels, transporters and enzymes (pKi < 5).
BGC20-1531 competitively antagonizes PGE(2)-induced vasodilatation of human middle cerebral (pK(B) 7.8) and meningeal (pK(B) 7.6) arteries in vitro, and PGE(2)-induced increase in canine carotid blood flow in vivo.

物理化学性质&存储条件

分子量	529.004
分子式	C26H25ClN2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride

参考文献

1. Maubach KA, et al. Br J Pharmacol. 2009 Jan;156(2):316-27.

2. Antonova M, et al. J Headache Pain. 2011 Oct;12(5):551-9.

BGC20-1531 (PGN-1531;AP 1531;BGC 20-1531)

生物&药学活性

物理化学性质&存储条件

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BGC20-1531 (PGN-1531;AP 1531;BGC 20-1531)

生物&药学活性

物理化学性质&存储条件

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