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BFstatin

Chemical Structure : BFstatin

CAS No.:

BFstatin (175C05)

货号: PC-23181Not For Human Use, Lab Use Only.

BFstatin (175C05) is a small molecule inhibitor of V. vulnificus BrpR with EC50 of 8.01 uM, a transcriptional regulator for biofilm genes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BFstatin (175C05) is a small molecule inhibitor of V. vulnificus BrpR with EC50 of 8.01 uM, a transcriptional regulator for biofilm genes.
BFstatin does not interfere with bacterial growth or exhibit cytotoxicity to the human epithelial cell line.
BFstatin interacts with BrpR to inhibit its binding to target promoter DNA.
BFstatin interacts directly with BrpR with MST KD of 7.14 uM.
BFstatin affects the expression of the BrpR regulon.
BFstatin interrupts the development of the biofilm matrix, suppresses the biofilm formation of Vibrio vulnificus.

物理化学性质&存储条件

分子量 272.70
分子式 C12H14ClFN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N1-(2-chloro-5-fluorophenyl)-N3-propylmalonamide

参考文献

1. Hojun Lee, et al. Front Microbiol. 2024 Sep 9:15:1468567.

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