BFL1 inhibitor 20

Chemical Structure : BFL1 inhibitor 20

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货号: PC-23607Not For Human Use, Lab Use Only.

BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.

规格	价格	库存	数量
50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.
BFL1 inhibitor 20 is inactive in BCL2, BCL-xl, or MCL1.
BFL1 inhibitor 20 exhibits potent activity on caspase activation in the SUDHL1 cell line when combined with AZD5991(EC50=0.35 uM).
BFL1 inhibitor 20d emonstrated a cell death phenotype in SUDHL1 and OCILY10 cell lines and in the in vivo

物理化学性质&存储条件

分子量	439.35
分子式	C22H25Cl2FN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(((1R,3R)-3-aminocyclopentyl)oxy)-3-fluorophenyl)-N-((S)-1-(4-chlorophenyl)ethyl)acrylamide hydrochloride

参考文献

1. Palisse A, et al. J Med Chem. 2024 Dec 6. doi: 10.1021/acs.jmedchem.4c01995.