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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-BFL-1 inhibitor 4E14
BFL-1 inhibitor 4E14

Chemical Structure : BFL-1 inhibitor 4E14

CAS No.:

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BFL-1 inhibitor 4E14 (4E14)

货号: PC-72541Not For Human Use, Lab Use Only.

4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction).
    4E14 targets a unique C55 residue in the BFL-1 groove.
    4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
    4E14 (BFL-1 BH3 inhibitor 4E14) blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.

    物理化学性质&存储条件

    分子量 408.579
    分子式 C19H28N4O2S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-acetamido-N-(2-((2-(dimethylamino)ethyl)disulfanyl)ethyl)-3-(1H-indol-3-yl)propanamide

    参考文献

    1. Edward P Harvey, et al. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6.

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