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BFA1

Chemical Structure : BFA1

CAS No.: 263563-30-0

BFA1 (Burkholderia Fix Activator 1)

货号: PC-21549Not For Human Use, Lab Use Only.

BFA1 is a specific small-molecule activator of Burkholderia FixLJ signaling pathway, inhibit the virulence of multiple pathogenic Burkholderia species.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BFA1 is a specific small-molecule activator of Burkholderia FixLJ signaling pathway, inhibit the virulence of multiple pathogenic Burkholderia species.
BFA1 inhibit B. dolosa virulence in THP-1-derived macrophages in a fixLJ-specific manner.
BFA1 is predicted to bind to FixL at the ATP/ADP-binding pocket of the histidine kinase domain.

物理化学性质&存储条件

分子量 404.47
分子式 C24H24N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-hexyl-7-hydroxy-3-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)-2H-chromen-2-one

参考文献

1. Kathryn E Mansour, et al. bioRxiv. 2023 Dec 2:2023.12.02.569726.

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