BF738735 | PI4KB inhibitor | Probechem Biochemicals

Chemical Structure : BF738735

CAS No.: 1436383-95-7

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BF738735 (BF 738735, BF-738735)

货号: PC-63341Not For Human Use, Lab Use Only.

BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM).

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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生物&药学活性

BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM).
BF738735 blocks viral RNA replication with IC50 of 77 nM in luciferase assays, strongly inhibits CVB3 and EV71 replicon replication at 1-5 uM.
BF738735 reduces the PI4P levels at the Golgi complex through a direct inhibition of PI4KIIIβ activity.

物理化学性质&存储条件

分子量	426.466
分子式	C21H19FN4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol

参考文献

1. MacLeod AM, et al. ACS Med Chem Lett. 2013 May 8;4(7):585-9.

2. Melia CE, et al. Cell Rep. 2017 Oct 17;21(3):587-599.

3. van der Schaar HM, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81.

4. Ulferts R, et al. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2627-38.

BF738735 (BF 738735, BF-738735)

生物&药学活性

物理化学性质&存储条件

参考文献

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BF738735 (BF 738735, BF-738735)

生物&药学活性

物理化学性质&存储条件

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