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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-BEBT-908
BEBT-908

Chemical Structure : BEBT-908

CAS No.: 1235449-52-1

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BEBT-908 (BEBT908, CUDC-908)

货号: PC-35868Not For Human Use, Lab Use Only.

BEBT-908 (BEBT908, CUDC-908) is a novel potent, dual PI3K/HDAC inhibitor with nanomolar IC50 values of <0.1 uM (PI3Kα) and 0.1-1 uM (HDAC).

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BEBT-908 (BEBT908, CUDC-908) is a novel potent, dual PI3K/HDAC inhibitor with nanomolar IC50 values of <0.1 uM (PI3Kα) and 0.1-1 uM (HDAC).
BEBT-908 inhibited multiple pathways, including JAK/STAT3, MAPK/ERK and NF-κB, and induced apoptosis and cell cycle arrest at G1 phase in these cells.
Dual PI3K/HDAC inhibition via BEBT-908 is superior to the inhibition of PI3K or HDAC alone.

物理化学性质&存储条件

分子量 507.573
分子式 C23H25N9O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Pyrimidinecarboxamide, N-hydroxy-2-[methyl[[2-[6-(methylamino)-3-pyridinyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]amino]-

参考文献

1. US 20120088764 A1 20120.

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