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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-BDTX-189
BDTX-189

Chemical Structure : BDTX-189

CAS No.: 2414572-47-5

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BDTX-189 (Tuxobertinib, BDTX189)

货号: PC-73140Not For Human Use, Lab Use Only.

BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants.
BDTX-189 (Tuxobertinib) shows KD value s of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively.
BDTX-189 (Tuxobertinib) inactivates multiple allosteric ERBB mutants in vivo, achieves dose-dependent regression of allosteric HER2 and EGFR tumors.

物理化学性质&存储条件

分子量 561.03
分子式 C29H29ClN6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-(2-morpholinoethoxy)quinazolin-6-yl)acrylamide

参考文献

1. Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.

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