Silevertinib (BDTX-1535) | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : BDTX-1535

CAS No.: 2607829-38-7

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BDTX-1535 (Silevertinib, BDTX1535)

货号: PC-21566Not For Human Use, Lab Use Only.

Silevertinib (BDTX-1535) is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC.

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5 mg	￥2280	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
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生物&药学活性

Silevertinib (BDTX-1535) is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC.
BDTX-1535 achieves potent anti-tumor activity against EGFR alterations and amplification across models including NSCLC and GBM PDX and intracranial tumors.

物理化学性质&存储条件

分子量	561.06
分子式	C30H30ClFN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(4-((3-chloro-2-fluorophenyl)amino)-7-(((1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl)ethynyl)quinazolin-6-yl)-4-morpholinobut-2-enamide

参考文献

1. Matthew O'Connor, et al. Cancer Res (2023) 83 (7_Supplement): 3396.

BDTX-1535 (Silevertinib, BDTX1535)

生物&药学活性

物理化学性质&存储条件

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BDTX-1535 (Silevertinib, BDTX1535)

生物&药学活性

物理化学性质&存储条件

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