BDP9066 |CAS: 2226507-04-4 Probechem Biochemicals

Chemical Structure : BDP9066

CAS No.: 2226507-04-4

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BDP9066 (BDP-9066;BDP 9066)

货号: PC-63523Not For Human Use, Lab Use Only.

BDP9066 (BDP-9066) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM, >100-fold selectivity over related ROCK1 or ROCK2.

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5 mg	￥1580	In stock
10 mg	￥2480	In stock
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生物&药学活性

BDP9066 (BDP-9066) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM, >100-fold selectivity over related ROCK1 or ROCK2.
BDP9066 shows similar activity against MRCKα and MRCKβ.
BDP9066 inhibits MLC2 phosphorylation (EC50=64 nM) and blocks SCC12 squamous cell carcinoma motility and invasion.
BDP9066 reduces MRCKα S1003 autophosphorylation and skin papilloma outgrowth in chemical carcinogenesis model of murine squamous cell carcinoma.

物理化学性质&存储条件

分子量	348.454
分子式	C20H24N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-(3-(pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,8-diazaspiro[5.5]undecane

参考文献

1. Unbekandt M, et al. Cancer Res. 2018 Apr 15;78(8):2096-2114.

BDP9066 (BDP-9066;BDP 9066)

生物&药学活性

物理化学性质&存储条件

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BDP9066 (BDP-9066;BDP 9066)

生物&药学活性

物理化学性质&存储条件

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